There was a time when Apatow's name would make me very excited for a project, but over the past few years the quality of his work has been on a decline. This movie doesn't come close to its sort-of prequel "Knocked Up." In fact, much of it was a bore. Is it supposed to be a comedy? There were some laughs, but few and far between.
Instead of "This Is 40", I recommend you watch "I Love You Man."