Greg Dorr’s review published on Letterboxd:
It may have been that The Lost Weekend was seen as groundbreaking in its day, but I wouldn't think so. Ever since the silent era, movies have pedantically warned audiences against such nefarious evils as drink, drugs, and loose morals. Surely with Prohibition in the rear-view mirror, the concept of alcoholism was not news to anyone (even though the mere sight of a liquor bottle is enough to shock the sensibilities of provincial New Yorkers throughout the film). However, Wilder's dialog is typically tight and colorful, and Milland is quite good, even though the entire project is almost completely unremarkable by today's standards.