A legendary genre mash-up. Loved the look, loved the music, and loved the overwhelming strangeness. Professor Hess has one of my all-time favorite villain motivations, but I'd hate to give anything away.
Thought it was fun how none of the characters' reactions match the situation. It's a hard thing to pull off in a movie, but it totally sells the viewer on the alien nature of this alternate reality.
If I had a criticism, it would be the story doesn't fully explore the horrible implications of the protagonist's actions. Moral ambiguity is one thing, but it helps to feel the creators understand the inherent misogyny. It would have been nice to have another character ask, "But what about...?" The answer would be a firm "Not my problem."
The American Astronaut hits that rare balance of artistic and accessible. I'd compare it to Superstarlet A.D. as an artsy low-budget black-and-white sci-fi experience. If you liked one, I recommend seeing the other.