I can only imagine that this and Grave of the Fireflies would make for an incredibly bleak, depressing double feature - yet much like Isao Takahata's film, what makes Murakami's film work as well as it does can be boiled down to how there is a feeling of hope that comes forth within the unfortunate circumstances, even if you know the outcome.
Nevertheless, from watching When the Wind Blows, the animation would be one thing that already catches your eye, but it only becomes even more heart-wrenching from there. We're watching an ordinary couple in love trying to retain a sense of normalcy when all hope seems to be lost, for Murakami only depicts their naive nature in the most loving manner - only as intense sadness starts to cloud the world outside of their home afterwards.
This isn't an easy film to watch, but it's absolutely rewarding in all the best ways.