Rival comic book store owners wage war on each other while trying to get their hands on a massive collection of vintage comics from a little old lady who is reluctant to sell.
If this movie had fully embraced the mean streak it shows in its second half,, "Comic Book Villains" could have been a slacker/nerd culture cult classic ala "Fanboys" or "Clerks." As it is, it's a slightly half-baked, but mildly entertaining heist/caper comedy set in the comic-book world, with a great cast incl. Donal Logue, DJ Qualls, and Natasha Lyonne. Your mileage may vary depending on your level of comic book fandom.